Heart Disease
Risk Is More Than High
Cholesterol…
Heart disease (or cardiovascular disease) refers to
various disorders affecting blood vessels that feed the
heart, most often atherosclerosis.
Contributing factors are diverse and interactive,
including genetics, diet and lifestyle, age, emotions,
hormonal and biochemical balance in the
body.
The number one killer in America today, heart
disease claims as many lives as the next leading causes
of death combined, including cancer, accidents and
AIDS.
Nevertheless, this deadly disease is often
preventable. Early identification of underlying and
early indicators can significantly impact the disease,
thereby halting its progression.
Nearly 50% of all heart attack victims have normal
levels of traditional early warning markers for
cardiovascular disease (CVD), including total
cholesterol. For this reason, improved clinical tools
are needed to identify patients with a predisposition to
CVD who can benefit from timely, preventative
intervention. The Comprehensive Cardiovascular
Assessment measures state-of-the-art, independent
markers that illuminate the clinical complexity of
CVD.
What factors contribute to cardiovascular
disease?
Ø
High
blood pressure
Ø
High
blood cholesterol
Ø
Tobacco
smoke
Ø
Physical inactivity
Ø
Obesity
and overweight
Ø
Diabetes (Type 2)
Ø
Increasing age
Ø
Male
gender
Ø
Race
[Source: www.americanheart.org]
Coronary Vascular
Disease (CVD)
Based on the latest
advancements in cardiovascular research, this assessment
measures the most important CVD markers available, including
crucial new independent factors, a diverse array of
lipoproteins, and two computed ratios.
All of these
advanced markers play a critical role in assessing the
biochemical environment underlying cardiovascular health.
This information allows Dr. Hardy to accurately address
abnormalities relating to heart and vascular
diseases.
It is currently
estimated that 57 million Americans—over one-fifth of the
entire U.S. population—suffer from
some form of cardiovascular disease.
Testing is strongly
recommended for patients with the following history or
medical conditions
Ø
Family
history of cardiovascular disease
Ø
Personal
history of myocardial infarction, peripheral artery
disease,
or coronary artery disease
Ø
Obesity
Ø
Diabetes
Ø
Hypertension
Ø
Thyroid
disorders
Ø
Stress
Ø
Chronic
illness (including chronic fatigue)
Ø
Diets high
in saturated and trans fats
Ø
Sedentary
lifestyle
Ø
Use of
alcohol, nicotine, drugs (including certain medications)
Ø
Use of oral
contraceptives
Ø
Hormonal
imbalances (estradiol, cortisol, insulin, melatonin)
Ø
Post-menopause
Ø
Renal
disease
What difference will
having this set of comprehensive test results make to
me?
Prevention! Many of
the multiple risk factors for cardiovascular disease can be
reduced or eliminated with individualized integrative
therapies.
When abnormalities
are found with this panel of indicators, a treatment plan
can be customized to your specific needs and risk factors.
This plan typically includes lifestyle, diet and nutritional
recommendations.
Heart Disease Risk Marker’s
Total
Cholesterol
Elevated levels have long been associated with increased
Coronary-Vascular Disease (CVD) risk
If high, suspect
Ø
Dietary
sources (diets high in animal fats, eggs, organ
meats)
Ø
Diabetes
Ø
Hypothyroidism
Ø
Biliary
obstruction
Ø
Familial
hyperlipidemia types 2a, 2b, 3 or 5
Ø
Pregnancy
Ø
Chronic
stress
HDL
Patients with high levels of HDL have been shown to be at lower
risk of CVD than those with lower levels.
If low, suspect
Ø
Genetic factors
Ø
Poor dietary habits, intake of hydrogenated oils
Ø
Sedentary lifestyle
Ø
Decreased testosterone levels (aging)
Ø
Polycystic ovary syndrome
Ø
Growth hormone deficiency
Compounded probability of coronary artery disease if high
Lp(a), or in smokers
Total Chol/HDL
Ratio The higher
the ratio, the greater the risk.
LDL
Cholesterol
The most atherogenic of the lipoproteins, it constitutes the
majority of the cholesterol found in the
serum.
If high, suspect
Ø
Excessive
consumption of unfiltered coffee,
Ø
Meat
fat
Ø
Hydrogenated oils
Ø
Dairy
products
Higher incidence of
M.I. (High LDL is the best predictor of M.I. for men aged
40-60)
Familial pattern of
hypercholesterolemia (1:500 general
population)
Non-LDL
Cholesterol
LDL + VLDL , less
than 160 mg/dl is suggested
Triglycerides
High triglyceride levels are an indisputable risk factor for
CVD; increasingly shown to be responsive to the carbohydrate
concentration in the body.
If high, suspect
Ø
High fat or
high carbohydrate diet
Ø
Familial
hyperlipidemia types 1, 2b, 3, 4 or 5
Ø
Diabetes,
insulin insensitivity
Ø
Hepatitis,
significant liver disease
Ø
Hypothyroidism
Ø
Alcoholism
Ø
Pancreatitis
Ø
Atherosclerosis
Higher incidence of
ischemic heart disease (with elevated Lp(a) and
fibrinogen)
Progressive coronary
artery disease--post angioplasty (with low Apo
A-1)
Hs-CRP
(high sensitivity c-reactive
protein)
A general marker of inflammation or infection in the vascular
network. Elevated levels have been shown in individuals with
mild or subclinical CVD. The high sensitivity assay (hs-CRP)
used for this report can detect increases signaling the early
stages of disease.
If high, suspect
Ø
Inflammatory processes
Ø
Acute-phase processes (post surgery, neoplasm,
infection)
Ø
Diabetes
Ø
Smoking
Ø
Subclinical or reactivated infections with Chlamydia
pneumoniae, H. pylori, EBV, HSV
Higher incidence of CVD even without other laboratory or
familial risk factors
Compounded probability of CVD with high CRP and fibrinogen
Fibrinogen
In states of tissue injury/inflammation, elevated fibrinogen is
correlated with early CVD, and is a better marker of risk for a
coronary event than is elevated cholesterol.
If high, suspect
Ø
Smoking
Ø
Genetic variability
Ø
Insulin resistance, diabetes
Ø
Pregnancy
Ø
Increased likelihood of cerebral infarction
Compounded likelihood with elevated blood viscosity
parameters
Ferritin
The best
measure of iron deficiency, elevated ferritin is also an
important maker of cardiovascular health.
If high, suspect
Ø
Ischemic
heart disease
Ø
Iron
overload
Ø
Hemo-chromatosis
Homocysteine
Many studies, including the
Physicians’ Heart Study, have demonstrated the association
between elevated homocysteine levels and CVD.
If high, suspect
Ø
Genetic homocysteinemia
(hetero- or homozygous)
Ø
Nutritional deficiencies of
B12, B6, folate, serine (which may impair methionine
metabolism)
Ø
High coffee and cigarette
use
Ø
Metformin (Glucophage) usage
Ø
Anticonvulsant medications
Ø
Hepatic toxicity interfering
with methylation pathway
Compounded CVD likelihood if
hypertension and smoking are also present
LP (a)
Apolipoprotein(a) complexed with LDL. Lp(a) is associated with
development of atherosclerosis similarly to LDL; strong
indicator for cerebrovascular disease.
If high, suspect
Ø
Genetic predisposition
Ø
Excessive intake of partially hydrogenated oils
Ø
Low fiber, low vegetable-based diet
Ø
Hypothyroidism
Ø
Post-menopausal elevation
Ø
Diabetes, particularly with central obesity
Ø
Chronic renal insufficiency
Ø
Simvistatin therapy
Compounded likelihood of CV disease if also high LDL and/or
total cholesterol
APO
A-1
If high, suspect
Ø
High stress
Ø
Genetic predisposition
Ø
Dietary factors (see HDL)
Ø
Growth hormone or testosterone deficiencies
Ø
Polycystic ovary syndrome
Apo B / Apo A-1
ratio
is in the OPTIMAL
range, suggesting cardioprotection. This ratio is regarded
as an important component of cardiovascular risk, the
apolipoproteins being a more refined gauge of risk than HDL
& LDL levels .
Here are additional
tests for Heart Disease that may help determine
the underlying cause of
cardiovascular disease
Nutrition
Imbalances in vitamins, minerals, amino acids, and essential
fats can impact a variety of cardiovascular
functions.
Fatty Acids
Certain essential fats from the diet guard against hardening of
fatty deposits in the arteries and influence blood
pressure.
Oxidative Stress
A healthy antioxidant defense helps the body defend against
heart disease progression mediated by unstable free
radicals.
Amino Acids
Imbalances in amino acids such as taurine, methionine, and
arginine can contribute to the development of heart disease and
its symptoms.
Heavy Metal Toxicity
Hypertension and other cardiovascular problems have been linked
to toxic and nutrient element imbalances.
Melatonin
Decreased melatonin promotes increased night-time sympathetic
nervous system activity, in turn linked to heart
disease.
Genetic Predisposition
Inherited defects in methylation or control of inflammation in
the body can influence the course of heart
disease.
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