Hormone Guide | Introduction

Estrogens:  

The body produces three types: 

Estrone (E1):
E1 is in equilibrium with E2 and therefore can be approximated by knowing the E2 level. There is no need to supplement with E1.

In fact, metabolites of E1 are thought to be carcinogenic. 

Estradiol (E2):
The strongest form of estrogen and when deficiency exists it causes: hot flashes, night sweats, insomnia, memory loss and emotional lability.

It is best supplemented topically because PO supplementation is known to reduce Growth Hormone levels. 

Estriol (E3):
Considered the weakest estrogen, but also the protective estrogen.

Is used widely to treat vaginal dryness/atrophy and as a safe estrogen replacement for breast cancer survivors.

It is generally added whenever E2 is supplemented in the form of "Biest"
(most often in a 1:4 ratio of E2 to E3).

The recent medical literature strongly suggests that estriol is most helpful for autoimmune conditions, e.g., multiple sclerosis. 

Progesterone:
The bio-identical hormone known to block or protect against the proliferative effects of Estrogen (E2). It is protective of breast and endometrial tissue.

When replaced in physiologic doses, it stabilizes mood, increases bone mineralization, reduces PMS and post-menopausal symptoms, and decreases
cancer risk.

It is best supplemented topically or sublingually. 

Progestin:
Is used to refer to a group of synthetic progesterones that have high risk effects (increased breast and endometrial cancer risk, heart disease, stroke and pulmonary embolism) since it is more than a single molecule.

These are dangerous compounds and should be avoided. 

DHEA: 
An adrenal hormone which may also be converted to testosterone, cortisol, and estrogen. DHEA supplementation in addition to supporting adrenal health/energy metabolism (when low) will readily optimize testosterone levels in women. 

DHEA-S:  
The sulfate form of DHEA which cannot be accurately assessed through saliva. 

Testosterone:  
The major sex hormone in males produced in the testes, and in women in the adrenal glands and ovaries. It is essential for sexual function, cardio-protection, stamina, muscle strength, bone density and stable sugar metabolism.

In males, it is prostate gland-protective.  

Cortisol: 
The adrenal’s primary glucocorticoid, secreted in a known 24-hr pattern (diurnal rhythm) essential for sugar metabolism and immune modulation.

It is foundational for energy production and optimal thyroid function.